Principal Investigator: Frank G. Hillary, Ph.D.

Over the past 15 years my research has focused on understanding the consequences moderate and severe traumatic brain injury taking perspectives from cognitive neuroscience and clinical rehabilitation. To examine the broad consequences of TBI on patient outcome, we use large databases to understand the factors that influence TBI outcome including behavioral (e.g., alcohol use) and demographic (e.g., gender, age) risk factors for TBI and outcome stratification. In addition, the work in my lab has used functional MRI and connectivity modeling to understand systems-level plasticity after moderate and severe traumatic brain injury.  Over the past decade the functional MRI literature has shifted to focus on examining connectivity in brain networks which now compliments the first generation of fMRI studies focused on the localized responses during perturbation (i.e., task). During this transition I have led collaborative efforts to employ these methods, pioneering the first TBI studies using brain connectivity measures and advanced statistical analyses (e.g., graph theory) and the few studies in the literature examining brain network changes longitudinally after TBI.  Since we published the first longitudinal graph theory study in 2009, we have continued these efforts examining early recovery windows using longitudinal methods including data collection at multiple hospital facilities. In addition our most recent work focuses on the commonly observed phenomenon of hyperconnectivity following injury and linking these effects over the life-span as possible predictors of neurodegeneration including recent collaborations to investigate these effects in mild cognitive impairment.


Current Graduate Students

Samantha Vervoordt

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I am a fifth year graduate student in Dr. Frank Hillary’s lab. I received my B.S. in Biopsychology from Tufts University in 2019. My undergraduate research primarily focused on examining the effects of localized lesions on language and learning through both zebra finch and rat models. Broadly, I am interested in the chronic effects of brain injury, specifically as they relate to risk for abnormal aging later in life. For my Master’s, I examined the effects of depression on cognitive decline and hippocampal volume in older adults with a lifetime history of moderate to severe TBI. My other projects in the lab have examined acute hospital outcomes for older adults with pre-existing stroke history. For my dissertation, I am examining whether a symptom-based approach to mood disturbances in TBI recovery is better suited to predict social outcomes and neural network changes compared to more traditional models, which treat such disorders as distinct and unitary syndromes.

Andrew Cwiek

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I am currently a third-year graduate student in Dr. Frank Hillary's lab. I earned my B.S. in Cognitive and Computational Neuroscience from Michigan State University. Before coming to Penn State, I worked as a post-baccalaureate research assistant in the Clinical Neuroscience & Neuropsychology Lab at the University of Nebraska – Lincoln, as well as a rehabilitation trainer for survivors of TBI at Quality Living Incorporated in Omaha. Broadly, I am interested in improving the reproducibility and applicability of traumatic brain injury research through data sharing; simulation; and advanced statistical (e.g. machine learning) techniques. For my Master’s, I examined the current state of machine learning's integration into traumatic brain injury research, with a special focus on the need for methodological transparency. Additionally, I am currently investigating structural changes to white matter pathways in the chronic stages of msTBI.

Hollie Mullin

I am a first year graduate student in Dr. Frank Hillary’s lab. I received my B.S. degree in Behavioral Neuroscience from the University of Kansas in 2020. My undergraduate research largely focused on understanding the mechanisms of language perception and production. After graduating, I worked at Duke’s Brain Imaging Analysis Center (BIAC) for 2 years. At BIAC, I utilized fMRI and DTI to examine age-related brain changes in healthy adults using graph theory, both at rest and during visual search tasks. In Dr. Hillary’s lab, I would like to combine neuropsychological assessment and neuroimaging to examine how abnormal aging and TBIs affect cognitive functioning and brain network organization. I also hope to address replicability issues in neuroimaging so we can better predict long term outcomes and enhance rehabilitation interventions for patients.


Staff

Liz Rebuck

I am the Research Coordinator in the Hillary Lab. I received my B.A. in Psychology from The University of New Hampshire in 2021. As as undergraduate, I worked for two years as a research assistant working on a variety of projects that included the psychophysiology of emotions, cognitive appraisals, and the prevention of interpersonal violence in schools. Currently, I also have a role as an interviewer for the CIRCLES study which focuses on familial aggression in the home. In the future, I plan to pursue a Phd in clinical psychology to satisfy my need for acquiring knowledge and helping others.

Spencer Chase

I graduated from Virginia Polytechnic Institute and State University (Virginia Tech) in 2022 with a B.S. in Experimental Neuroscience. I have previous done behavioral and computational work looking at learning and memory in those diagnosed with Parkinson’s Disease. I have also analyzed the impact of cigarette smoking on the white matter and pial surfaces of the brain through various fMRI scanning protocols. I am currently working in both the Cognitive Aging and Neuroimaging Laboratory with Dr. Nancy Dennis, as well as the Clinical Neuropsychology Laboratory with Dr. Frank Hillary to further explore my interests in neuroimaging and statistical analysis. In my free time I like to run, play video games, learn about technology, and travel.

Jason Staph

Currently an independent collaborator in the Hillary Lab. After spending a little more than 20 years in various technology positions in several industries, I'm working to balance a full time career against a complete pivot back to my passion; neuropsychology. I'm particularly interested in applying my technology skillset to the more computational tasks in fMRI studies. I still don't know what I want to be when I grow up.

Adriana Méndez-Fernández

I completed my bachelor's degree in Special Education with emphasis on Behavioral and Emotional Disorders at the University of Puerto Rico, Río Piedras Campus in June 2022. After my graduation, I became a research assistant at Penn State University and have been engaged in projects associated with: The relation of Post Traumatic Stress Disorder to aggression in the household; the interactions between parents and children when exposed to stressful circumstances; the portrayal of women who have experienced Intimate Partner Violence; Traumatic Brain Injuries’ effects in women who have experienced Intimate Partner Violence. In a future, I hope to pursue PhD in Clinical Psychology.

Gloria Lan

I‘m a research assistant in the Hillary lab. I received dual B.S degree in Biology and Psychology here at Penn State in 2022. As an undergrad, I worked as a research assistant for 2 years in the Yingwei Mao Neurobiology Lab, focusing on examining how abnormal neural progenitor cell proliferation and differentiation may lead to psychiatric disorders through mouse models. Through this, I became increasingly interested in the cognitive and behavioral impact of neurogenesis. Currently, I aim to integrate my previous experience in neurobiology with clinical psychology, as well as learning new neuroimaging and neuropsychological assessment techniques. Eventually, I intend to pursue a PhD, so I may have an opportunity to further explore cross-disciplinary research in the field of clinical neuropsychology.


Undergraduate Research Assistants

Wes Meyer Emily Carter

I’m Wes Meyer, a Junior at Penn State University Park pursuing a psychology/neuroscience major with a philosophy minor. As I learn more about psychology, the more I become more confident in my intent to pursue a medical degree in Neurology. Neuroscience is interesting to me due to the current lack of understanding concerning the brain. Feeling as though I am helping build the current knowledge regarding brain function is incredibly exciting, allowing me to look forward to all the work I do in the lab. 

I am a Junior pursuing my BS In Psychology with an emphasis in Neuroscience. I am particularly interested in abnormal psychology, the impact it has on daily functioning and the areas of the brain that are being affected. Outside of school, I enjoy reading and spending time with my friends and family. After graduation, I plan to pursue a PhD in Clinical Psychology with a specific specialization in neuropsychology.

Rida Hamid

I am a third-year Schreyer Scholar pursuing a BS in Biobehavioral Health with minors in Global Health and Biology. Through my time at the lab, I have found great interest in learning about the effects of traumatic brain injury on neural networking and mental health. I also wish to better explore access and equity within imaging research. Beyond my role as a research assistant, I also participate in Ethics in Science and Medicine, Days for Girls, and the Nittany AI Challenge. After graduation, I plan on attending medical school to further pursue my interests in healthcare.

Quinn Pritchard

I am a third-year Schreyer Honors scholar pursuing a BS in Biology with a minor in German. I am interested in how the anatomical damage caused by traumatic brain injuries can affect the physiological functioning of the brain and how these alterations in functioning can be compensated for by emerging therapies. Outside of being a research assistant, I am involved in Alpha Kappa Psi, a professional, co-ed business fraternity. After graduation, I plan on integrating my passions for science and business into a career in consulting or pharmacy.

 

Lab Alumni

Emily Grossner

Emily is currently a neuropsychology postdoctoral fellow at VA Palo Alto. She recently completed her clinical internship at VA Palo Alto. She received my B.A. in Psychology from Franklin & Marshall College in Lancaster, PA in 2012. Following her undergraduate career, she earned her M.S. in Experimental Psychology with a focus in neuropsychology from Saint Joseph's University in Philadelphia, PA in 2015. Her Master's thesis examined the validation of a new computerized assessment tool for evaluating concussion. Her work in Dr. Hillary's lab primarily focused on metacognitive deficit following moderate to severe TBI and its relationship with decreased gray matter volume and functional neural networks. Other work she has focused on in the lab includes investigating the impact of brain lesions on neural networks. Her dissertation continued her work of determining neural correlates of metacognition and expanded on investigations of how to best quantify metacognitive deficit following TBI.

Einat Brenner

Einat is currently a neuropsychology postdoctoral fellow at UC San Diego. She completed her clinical internship at the UCSD/VA San Diego training program. She earned her B.S. in Cognitive Neuroscience from Brown University in Providence, RI in 2015. During her undergraduate years, she spent 3 years working as a research assistant in the Advanced Baby Imaging lab and one year working in the Memory and Aging Program at Butler Hospital in Providence, RI. For her Master's thesis, she examined dynamic resting-state connectivity changes in individuals with MCI and healthy older adults. Another project she led involved examining changes in resting state connectivity following behavioral intervention in patients with mild cognitive impairment. Her dissertation investigated the relationship between connectivity, cognitive reserve, and behavior in individuals with TBI and MCI.

Rachel Bernier

Rachel Bernier earned her B.A. in Psychology from the College of the Holy Cross in Worcester, MA in 2011.  Following graduation Rachel spent two years working as a clinical research assistant for the Neuropsychology Program at Rhode Island Hospital in Providence, RI. Rachel joined the lab in 2013 and her graduate work examined the relationships between neural network dynamics, vascular health, and cognitive functioning in adults with moderate/severe TBI. Rachel received clinical training through the Penn State Psychological Clinic as well as on externship at Rhode Island Hospital. She completed her predoctoral internship at UC San Diego/VA San Diego and graduated from Penn State with her PhD in August 2020. Rachel is currently completing her postdoctoral fellowship in clinical neuropsychology at UC San Diego using neuroimaging techniques and genetics to understand sex differences in Alzheimer’s disease, with emphasis on modifiable risk factors.

Umesh "Umi" Venkatesan

Umi graduated Phi Beta Kappa with a bachelor’s degree in psychology from Johns Hopkins University. He later earned a doctoral degree in clinical psychology from Pennsylvania State University in 2017. His doctoral work in the Hillary Lab focused on functional connectivity and cognition in chronic moderate-to-severe TBI (msTBI), and his master's thesis provided some of the first data on resting-state connectivity alterations after msTBI. Clinically, he developed expertise in the evaluation of TBI, neuropsychiatric disorders, and neurodegenerative dementias. Umi completed a pre-doctoral internship in clinical neuropsychology at Brown University and a postdoctoral fellowship within the VA Boston Healthcare System before joining Moss Rehabilitation Research Institute (Philadelphia, PA) in 2019. As Director of the Brain Trauma Behavior Laboratory (https://mrri.org/brain-trauma-and-behavior-laboratory-bratbehavior-lab/), Umi continues his work in the neuropsychology/imaging of msTBI, with special interests in pre- and post-injury biopsychosocial factors contributing to long-term health.

Arnab Roy

Arnab Roy was a post-doctoral student in Dr. Frank Hillary’s lab. He has a B.E. in Electronics and Telecommunications from Mumbai University, Maharashtra, India, M.S. in Computer Science, and Ph.D. in Bioengineering from Binghamton University, NY, U.S.A. His current research involves developing computational techniques for discovering regional-pairs in the resting-brain that show aberrant functional connectivity after traumatic brain injury (TBI) and understanding the manner in which the connectivity strength between these regions evolve during the recovery period. He is also interested in studying the non-stationary patterns of functional connectivity associated with TBI.

John D. Medaglia

John Medaglia graduated from Drexel University in 2008 with a B.S. in Psychology. He completed his post-doctoral work at the University of Pennsylvania, and after winning the NIH Director's Early Independence Award, continued on at the University of Pennsylvania in the Department of Psychology as a Research Assistant Professor. John's primary interest is the contribution of the cerebellum to working memory processing in distributed neural systems. His Master’s thesis investigated cerebellar relationships with forebrain regions and performance during working memory. His dissertation incorporates person-specific techniques for examining changes in neurocognitive processes following traumatic brain injury. He applies graph theory and effective connectivity approaches to fMRI time series to examine network changes and contributions to performance. Other interests include conceptual issues in the generalizability of aggregated statistical findings, neural network simulations, and dynamic systems approaches to brain functioning and cognition. In his remaining few hours, John enjoys sports, martial arts, strategy games and music. 

Deepa Ramanathan

Deepa Ramanathan graduated from the University of Vermont in 2005 with a B.S. in biobehavioral psychology and minor in chemistry. Deepa is interested in long-term cognitive, psychiatric, and functional consequences of TBI. Her master's thesis examined the relationship between dispositional optimism and long-term outcomes following TBI.  For her dissertation, she used data from the Pennsylvania Trauma Systems Foundation to describe the epidemiology of TBI in Pennsylvania, with a focus on examining short-term TBI outcomes in the elderly and in urban and rural locations.  Deepa completed her clinical internship in neuropsychology at the James A. Haley Veterans' Hospital in Tampa, FL.  She completed her Postdoctoral Residency in Rehabilitation Neuropsychology at The Johns Hopkins School of Medicine in Baltimore, MD. Deepa is now working as the inpatient rehab neuropsychologist for the TBI/stroke unit at Inova Mount Vernon Hospital. She also has an appointment as an Assistant Professor at Hopkins, teaching didactics to the rehab psychology and neuropsychology residents.

Kathy S. Chiou

Kathy Chiou graduated from the University of California, Berkeley in 2004 with a major in psychology and a minor in education.  Kathy has interests in examining metacognitive processes and factors that contribute to performance differences in this domain following moderate to severe TBI using neuropsychological assessment and neuroimaging methodologies.  She completed a master's thesis examining the relationship between executive functioning and metacognitive performance after moderate to severe TBI.  She expanded upon this work in her dissertation by using VBM and DTI methodologies to investigate the contribution of structural integrity to metacognitive performance following injury.  Kathy completed her clinical internship in neuropsychology at the University of Florida Health Science Center in Gainesville, Florida.  She completed her post-doctoral fellowship at Kessler Research Foundation in West Orange, NJ, and then took a tenure-track faculty position where she is now an Assistant Professor in the Department of Psychology at the University of Nebraska at Lincoln.

Kristine Dell

Kristine is a neuropsychology postdoctoral fellow with a research emphasis in traumatic brain injury and related disorders at the VA San Diego Medical Center. She completed her predoctoral clinical internship in TBI/Cognitive Rehabilitation and Neuropsychological Assessment also at the UCSD/VA San Diego training program. She earned her B.A. in Cognitive Science from the University of Virginia, after which she moved overseas to teach English as a second language in Lille, France. Kristine then served as a clinical psychometrist at Walter Reed National Military Medical Center working with military service members who suffered traumatic brain injuries for two years. While considering graduate school, she became a study coordinator at Walter Reed Army Institute of Research and the National Institutes of Health, studying the effects of chronic exposure to low level blast in both military and law enforcement personnel. For her Master’s, she examined variability in headache report and postural control following repeated exposure to blast in occupational training. Additional projects leveraged a state-wide hospital database to address possible risks conveyed by pre-existing health conditions, as well as under-represented groups that might experience increased risks for repetitive neurotrauma across Pennsylvania (i.e., patients discharged to homeless or to a legal authority), as well as symptom reporting in student-athletes and military personnel. Her dissertation examined the moderating effect of lifetime physical activity following moderate-severe TBI on neuropsychological performance as well as gray and white matter outcomes within the brain.


Undergraduate Student Alumni

  • Jeff Motter

  • Nick DePinto

  • Chase Dougherty

  • Ryan Hirst

  • Kristina Perterson

  • Becca Koenigsberg

  • Brian Trager

  • Divya Sriram

  • Dayna Kahl

  • Jason Blake

  • Sasha Terekhova

  • Wes Meyer

  • Monica Benson

  • Rianne Addler

  • Laura Boyden

  • Jerry French, Jr.

  • Bobby Mullin

  • Danielle Feger

  • Ashley Todd

  • Abby Renko

  • Suraj Mital

  • Emily Bryer

  • Sohayla Rostami

  •  Isabella Castro Colmenares

Research Coordinator Alumni

  • Neal M. Fitzpatrick

  • Tia Bochnakova

  • Britney Wardecker

  • Julia Slocomb

  • Tyler Snider

  • Rich Garcia

  • Mariah Hallman

  • Diana Priestley